Christine Brooke-Rose was born in Geneva, Switzerland to an English father and American-Swiss mother. She was brought up mainly in Brussels, and educated there, at Somerville College, Oxford and University College, London. During World War II she worked at Bletchley Park as a WAAF in intelligence, later completing her university degree. She then worked for a time in London as a literary journalist and scholar. She was married three times: to Rodney Bax, whom she met at Bletchley Park; to the poet Jerzy Pietrkiewicz; and briefly to Claude Brooke. On separating from Pietrkiewicz in 1968 she moved to France, teaching at the University of Paris, Vincennes, from 1968 to 1988. After she retired she lived in the south of France.
Her novel Remake (1996) is an autobiographical novel:
It is an autobiographical novel with a difference, using life material to compose a third-person fiction, transformed in an experiment whose tensions are those of memory — distorting and partial — checked by a rigorous and sceptical language which probes and finds durable forms underlying the impulses and passions of the subject. It is not a simple process of chronological remembering. Remake captures not facts but the contents of those facts, the feelings of a war-time child, the textures of her clothing, tastes and smells, her mother, an absent father, a gradual transformation into adulthood.
She shared the James Tait Black Memorial Prize for fiction for Such (1966).
She was also known as a translator from French, in particular of works by Robbe-Grillet.